I like anything that makes my life easier. Twitter Bootstrap is definitely in that category. It’s chock full of great stuff you can use right away with XPages. Here are two articles I wrote on Socialbizug.org:
Getting Started With Twitter Bootstrap – Part 1
First off, what IS Twitter Bootstrap? Well, right on their front page they say it is a “Sleek, intuitive, and powerful front-end framework for faster and easier Web development.” Okay, so what is it really? It’s a thing that provides stuff to make your XPages prettier. Too simplified? Okay. If you’ve been using OneUI in conjunction with the Application Layout control, it’s sort of like that. A tool that provides the bits and pieces to quickly and easily style your Web application with a modern look and feel.
Getting Started with Twitter Bootstrap – Part 2
Now let’s start using Twitter Bootstrap!
The grid system is really useful and super handy to understand (but you don’t have to use it and still get benefit out of Twitter Bootstrap).
The grid system is on their “Scaffolding” page. It creates a framework for you to place the controls and pieces of your page on.